Curcumin-galactomannosides mitigate alcohol-induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin

Mohan, R and Jose, S and Sukumaran, S and Asha, S and Sheethal, S and John, G and Krishnakumar, IM (2019) Curcumin-galactomannosides mitigate alcohol-induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin. In: Journal of Biochemical and Molecular Toxicology, 33 (6).

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Abstract

Alcoholic liver diseases are classified as one of the major reasons for worldwide morbidity and mortality. Curcuminoids exhibit a wide range of pharmacological activities that are beneficial for health, including hepatoprotective effects, but its clinical significance is limited due to poor oral bioavailability. In the present study, a novel formulation of curcumin as curcumin-galactomannosides (CGM) with enhanced oral bioavailability alleviated alcohol-induced liver damage in wistar rats with an increased potency compared to the unformulated natural curcuminoids (CM). Ethanol administration significantly elevated liver toxicity markers, lipid peroxidation and inflammatory markers with a simultaneous reduction in antioxidant defenses. Supplementation of CGM reversed all of the pathological effects of alcohol administration, almost close to the normal level, when compared with CM. Histopathology of liver tissue also confirmed the better protective effect of CGM, indicating the enhancement in antioxidant and anti-inflammatory effects as a function of bioavailability.

Item Type:	Journal Article
Publication:	Journal of Biochemical and Molecular Toxicology
Publisher:	John Wiley and Sons Inc.
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc.
Keywords:	alanine aminotransferase; alkaline phosphatase; antiinflammatory agent; antioxidant; aspartate aminotransferase; biological marker; catalase; curcumin; curcumin galactomannoside; galactomannan; gelatinase A; gelatinase B; glutathione peroxidase; interleukin 6; mannoside; messenger RNA; nitric oxide; superoxide dismutase; toll like receptor 4; tumor necrosis factor; unclassified drug; alcohol; collagenase; curcumin; Tlr4 protein, rat; toll like receptor 4, adult; alanine aminotransferase blood level; alcohol liver disease; alkaline phosphatase blood level; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; aspartate aminotransferase blood level; comparative study; controlled study; drug bioavailability; drug potency; hepatitis; histopathology; leukocyte count; lipid peroxidation; liver cell; liver function; liver protection; liver structure; liver tissue; liver toxicity; male; mRNA expression level; nonhuman; oxidative stress; rat; Wistar rat; alcohol liver disease; animal; drug effect; metabolism; oxidative stress; pathology, Animals; Collagenases; Curcumin; Ethanol; Hepatitis, Alcoholic; Male; Oxidative Stress; Rats; Rats, Wistar; Toll-Like Receptor 4
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	23 Dec 2022 06:38
Last Modified:	23 Dec 2022 06:38
URI:	https://eprints.iisc.ac.in/id/eprint/78529

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