Engaging Dynamic Surfactant Assemblies in Improving Metal Ion Sensitivity of a 1,4,7-Triazacyclononane-Based Receptor: Differential Optical Response for Cysteine and Histidine

Maiti, B and Dey, N and Bhattacharya, S (2019) Engaging Dynamic Surfactant Assemblies in Improving Metal Ion Sensitivity of a 1,4,7-Triazacyclononane-Based Receptor: Differential Optical Response for Cysteine and Histidine. In: ACS Applied Bio Materials, 2 (6). pp. 2365-2373.

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Abstract

Self-assembly as well as metal ion binding property of an amphiphilic, dansylated 1,4,7-triazacyclononane (TACN) probe have been investigated in the presence of various surfactant assemblies in aqueous media. As expected, the receptor molecule shows highly sensitive, but rather nonspecific, interaction with metal ions in the bulk water medium. Thus, to achieve the good specificity without dampening the sensitivity of the probe, we embedded the sensor in different surfactant assemblies, such as micelles and vesicles, and explored their metal ion sensing ability. Change in microenvironment by restricting conformational mobility and increasing local hydrophobicity renders a drastic improvement in selectivity and also sensitivity toward Cu2+. Further, the preformed Cu2+ complex of the probe was utilized for exclusive "turn-on" detection of both cysteine (green fluorescence) and histidine (blue fluorescence). The diverse complexation mode of interactions with these amino acids caused a distinct change in the monomer to aggregate ratio, which was reflected in different spectral response. Furthermore, the dansylated probe was involved in developing reusable paper strips for rapid on-site detection of both Cu2+ and cysteine. © 2019 American Chemical Society.

Item Type:	Journal Article
Publication:	ACS Applied Bio Materials
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society
Keywords:	Amino acids; Binding energy; Chemical sensors; Copper compounds; Fluorescence; Metal ions; Micelles; Probes; Surface active agents, Conformational mobility; Green fluorescence; Local hydrophobicity; Metal-ion binding properties; On-site detection; Selectivity and sensitivity; Sensitivity of the probe; Surfactant assemblies, Metals
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	23 Dec 2022 05:14
Last Modified:	23 Dec 2022 05:14
URI:	https://eprints.iisc.ac.in/id/eprint/78518

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