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Computational Modeling of Collective Cell Migration: Mechanical and Biochemical Aspects

Yang, Y and Jolly, MK and Levine, H (2019) Computational Modeling of Collective Cell Migration: Mechanical and Biochemical Aspects. [Book Chapter]

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Official URL: https://doi.org/10.1007/978-3-030-17593-1_1


Collective cell migration plays key roles in various physiological and pathological processes in multicellular organisms, including embryonic development, wound healing, and formation of cancer metastases. Such collective migration involves complex crosstalk among cells and their environment at both biochemical and mechanical levels. Here, we review various computational modeling strategies that have been helpful in decoding the dynamics of collective cell migration. Most of such attempts have focused either aspect – mechanical or biochemical regulation of collective cell migration, and have yielded complementary insights. Finally, we suggest some possible ways to integrate these models to gain a more comprehensive understanding of collective cell migration.

Item Type: Book Chapter
Publication: Advances in Experimental Medicine and Biology
Publisher: Springer New York LLC
Additional Information: The copyright for this article belongs to Springer New York LLC.
Keywords: biochemistry; cell adhesion; cell migration; embryo development; epithelial mesenchymal transition; fibrosis; information science; mathematical analysis; mathematical model; metastasis potential; molecular interaction; priority journal; wound healing; animal; biological model; cell motion; human; physiology, Animals; Cell Movement; Humans; Models, Biological; Wound Healing
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 06 Dec 2022 06:44
Last Modified: 06 Dec 2022 06:44
URI: https://eprints.iisc.ac.in/id/eprint/78269

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