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Synthesis, DNA photocleavage, molecular docking and anticancer studies of 2-methyl-1,2,3,4-tetrahydroquinolines

Bindu, PJ and Ravikumar Naik, TR and Mahadevan, KM and Krishnamurthy, G (2019) Synthesis, DNA photocleavage, molecular docking and anticancer studies of 2-methyl-1,2,3,4-tetrahydroquinolines. In: Chemical Biology Letters, 6 (1). pp. 8-13.

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Official URL: http://pubs.iscience.in/journal/index.php/cbl/arti...


2-Methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-ones (3a-g) were synthesized by one pot multicomponent aza Diels-alder reaction between N-arylimines with two molecules of N-vinyl-2-pyrrolidinone in presence of Sm(III)nitrate as catalyst in acetonitrile solvent at room temperature stirring. The photocleavage studies with 2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-ones (3a-g) revealed that almost all derivatives exhibited effective photocleavage of pUC-19 DNA at 365 nm, The The anticancer activities of newly synthesized compounds (3a-g) were more potent than doxorubicin on MCF-7 cells. The docking of PBR receptor (1EQ1) protein with newly synthesized THQ's (3a-g) exhibited well established bonds with one or more amino acids in the receptor active pocket.

Item Type: Journal Article
Publication: Chemical Biology Letters
Publisher: Integrated Science Publishing
Additional Information: The copyright for this article belongs to Integrated Science Publishing
Keywords: 2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-ones; Anticancer acivity; PUC-19 DNA Photocleavage; Sm(III)nitrate
Department/Centre: Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited: 02 Dec 2022 07:03
Last Modified: 02 Dec 2022 07:03
URI: https://eprints.iisc.ac.in/id/eprint/78143

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