Perfluoroarene induces a pentapeptidic hydrotrope into a pH-tolerant hydrogel allowing naked eye sensing of Ca 2+ ions

Maiti, B and Bhattacharjee, S and Bhattacharya, S (2019) Perfluoroarene induces a pentapeptidic hydrotrope into a pH-tolerant hydrogel allowing naked eye sensing of Ca 2+ ions. In: Nanoscale, 11 (5). pp. 2223-2230.

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Abstract

Self-assembly of a novel thermoresponsive, pyrene-appended oligopeptide sequence VPGKP (PyP) leads to the formation of spherical aggregates in water. The sizes of the globular aggregates of the peptide, PyP, strongly depend on the temperature of its suspension in water and decrease with the decrease in temperature showing a lower critical solution temperature (LCST) phenomenon. Furthermore, a pyrene-octafluoronaphthalene (OFN) 'pair' has been used as a supramolecular synthon to induce hydrogelation of PyP in the presence of an equimolar amount of OFN via complementary quadrupole-quadrupole interactions. The gel shows excellent pH tolerance and thixotropic behavior. Detailed studies suggest the existence of lamellar packing of the gelators in a right-handed helical fashion which yields globular aggregates. The globular aggregates are sticky in nature and form a gel via inter-globular interactions. Addition of Ca 2+ ions reinforces the mechanical strength and also reduces the critical gelator concentration of the native gel through coordination with the free -COO - group of the gelator. Therefore, the present hydrogel system could further be used as a naked eye sensor of Ca 2+ ions.

Item Type:	Journal Article
Publication:	Nanoscale
Publisher:	Royal Society of Chemistry
Additional Information:	The copyright for this article belongs to Royal Society of Chemistry.
Keywords:	Aggregates; Ions; Pyrene; Self assembly, Globular aggregates; Lower critical solution temperature; Oligopeptide sequences; Quadrupole interactions; Spherical aggregates; Supramolecular synthons; Thermo-responsive; Thixotropic behavior, Hydrogels
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	29 Nov 2022 06:19
Last Modified:	29 Nov 2022 06:19
URI:	https://eprints.iisc.ac.in/id/eprint/78056

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