Sharma, VK and Nandeesha, H and Vinod, KV and Subramanian, SK and Sankar, DS and Rajendran, R (2019) Comparison of anthropometric, cardiovascular, autonomic, baroreflex sensitivity, aerobic fitness, inflammatory markers and oxidative stress parameters between first degree relatives of diabetes and controls. In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13 (1). pp. 652-658.
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Abstract
Aim: We aimed at assessing cardiovascular risk of first degree relatives of diabetes (FDRD). Methods: A cross sectional study involving 90 apparently healthy normoglycemic volunteers aged between 15 and 50 years (45 FDRD and 45 FDRs of non-diabetics). We measured anthropometric parameters, baroreflex sensitivity, heart rate variability, cardiac autonomic function tests, and aerobic capacity, fasting blood glucose and insulin, lipid profile, inflammatory markers, nitric oxide and oxidative stress markers. Results: FDRD had significantly higher hip circumference and BF. Blood pressure, total peripheral resistance and cardiac output were comparable. FDRD had higher HR and rate pressure product. There were no significant differences in cardio-respiratory fitness (VO2max) and physical activity level. Time and Frequency domain parameters were comparable except for reduced NN50 and total power. Baroreflex sensitivity, 30:15 ratio and E: I ratio were significantly less in FDRD. Fasting glucose was comparable. Fasting Insulin, HOMA IR, HOMA B and HOMA AD were higher while HOMA S and QUICKI index were lower in FDRD. Lipid profile or lipid derived parameters were comparable except for higher non-HDLc in FDRD. Adiponectin was lower while Leptin and Leptin/apidonectin ratio was higher in FDRD. IL-6, hsCRP, TNF- alpha and MDA were significantly higher in FDRD, while TAS and nitric oxide were significantly lower in FDRD. Conclusion: Higher body fat percentage, with insulin resistance, deranged cardiac autonomic function, higher oxidative stress and inflammation, lower adiponectin and nitric oxide levels places FDRD at higher cardiovascular risk and necessitates early lifestyle modification/intervention.
| Item Type: | Journal Article |
|---|---|
| Publication: | Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
| Publisher: | Elsevier Ltd |
| Additional Information: | The copyright for this article belongs to Elsevier Ltd. |
| Keywords: | adiponectin; C reactive protein; glucose; high density lipoprotein cholesterol; insulin; interleukin 6; leptin; lipid; nitric oxide; tumor necrosis factor; adiponectin; insulin; nitric oxide, adolescent; adult; aerobic capacity; age; anthropometric parameters; Article; blood pressure; body height; body mass; body weight; cardiovascular risk; case control study; cross-sectional study; diabetes mellitus; first-degree relative; fitness; glucose blood level; heart output; heart rate variability; heart stroke volume; hip circumference; human; observational study; oxidative stress; physical activity; pressoreceptor reflex; priority journal; pulse pressure; vascular resistance; waist circumference; blood; body fat distribution; cardiovascular disease; diabetes mellitus; diabetic complication; female; insulin resistance; male; middle aged; oxidative stress; risk assessment; risk factor, Adiponectin; Adolescent; Adult; Blood Glucose; Body Fat Distribution; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus; Female; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Risk Assessment; Risk Factors |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 15 Nov 2022 09:30 |
| Last Modified: | 15 Nov 2022 09:30 |
| URI: | https://eprints.iisc.ac.in/id/eprint/78032 |
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