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Sirtuin 6 Is a Critical Epigenetic Regulator of Cancer.

Raghu, S and Prabhashankar, AB and Shivanaiah, B and Tripathi, E and Sundaresan, NR (2022) Sirtuin 6 Is a Critical Epigenetic Regulator of Cancer. [Book Chapter]

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Official URL: https://doi.org/10.1007/978-3-031-07634-3_10


Sirtuin 6 (SIRT6) is a member of the mammalian sirtuin family with deacetylase, deacylase, and mono-ADP-ribosyl-transferase activities. It is a multitasking chromatin-associated protein regulating different cellular and physiological functions in cells. Specifically, SIRT6 dysfunction is implicated in several aging-related human diseases, including cancer. Studies indicate that SIRT6 has a tumor-specific role, and it is considered a tumor suppressor as well as a tumor growth inducer, depending on the type of cancer. In this chapter, we review the role of SIRT6 in metabolism, genomic stability, and cancer. Further, we provide an insight into the interplay of the tumor-suppressing and oncogenic roles of SIRT6 in cancer. Additionally, we discuss the use of small-molecule SIRT6 modulators as potential therapeutics.

Item Type: Book Chapter
Publication: Sub-cellular biochemistry
Publisher: NLM (Medline)
Additional Information: The copyright for this article belongs to Springer Science and Business Media B.V.
Keywords: SIRT6 protein, human; sirtuin, animal; epigenetics; genetic epigenesis; genetics; human; mammal; metabolism; neoplasm, Animals; Epigenesis, Genetic; Epigenomics; Humans; Mammals; Neoplasms; Sirtuins
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 17 Nov 2022 05:03
Last Modified: 17 Nov 2022 05:03
URI: https://eprints.iisc.ac.in/id/eprint/77913

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