Shifting the Triangle-Square Equilibrium of Self-Assembled Metallocycles by Guest Binding with Enhanced Photosensitization

Saha, R and Sahoo, J and Venkateswarulu, M and De, M and Mukherjee, PS (2022) Shifting the Triangle-Square Equilibrium of Self-Assembled Metallocycles by Guest Binding with Enhanced Photosensitization. In: Inorganic Chemistry .

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Abstract

Shifting a triangle-square equilibrium in one direction is an important problem in supramolecular self-assembly. Reaction of a benzothiadiazole-based diimidazole donor with a cis-Pt(II) acceptor yielded an equilibrium mixture of a triangle ([C18H24N10O6S1Pt1]3 PtMCT) and a square ([C18H24N10O6S1Pt1]4 PtMCS). We report here the shifting of such equilibrium toward a triangle using a guest (pyrene aldehyde, G1). While both benzothiadiazole and pyrene aldehyde can form reactive oxygen species (ROS) in organic solvents, their therapeutic use in water is restricted due to aqueous insolubility. The enhanced water solubility of the benzothiadiazole unit and G1 by macrocycle formation and host-guest complexation, respectively, enabled enhanced ROS generation by the host-guest complex (G1′ ⊂ PtMCT) in water (G1′ = hydrated form of G1). The guest-encapsulated metallacycle (G1′ ⊂ PtMCT) has shown synergistic antibacterial activity compared to the mixture of macrocycles upon white-light irradiation due to enhanced ROS generation. The mechanism for such enhanced activity was established by measuring the oxidative stress and relative internalization of PtMCs and G1′ ⊂ PtMCT.

Item Type:	Journal Article
Publication:	Inorganic Chemistry
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to the American Chemical Society.
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry Division of Chemical Sciences > Organic Chemistry
Date Deposited:	09 Nov 2022 09:17
Last Modified:	09 Nov 2022 09:17
URI:	https://eprints.iisc.ac.in/id/eprint/77839

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