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A Pedagogical Introduction to Biomarker Detection in Surface-Based Biosensors

Prakash, P and Varma, M (2022) A Pedagogical Introduction to Biomarker Detection in Surface-Based Biosensors. In: Journal of Chemical Education .

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Official URL: https://doi.org/10.1021/acs.jchemed.2c00606


The field of biosensors is a burgeoning area of research and employs a large number of chemistry graduates. The impact of strip tests in detecting coronavirus was palpable during the recent COVID-19 pandemic and will further drive the biosensor industry. Despite their common usage, a coherent introduction to the basics of sensing remains missing from the chemistry curriculum. Through this work, key concepts of transport and noise interference in molecular sensing aimed at upper-level coursework are introduced. Exercises including teamwork activities are proposed for teaching and inquiry-based learning. The presented approach was effective in solidifying the concepts of molecular transport and competing binding kinetics. Furthermore, students are introduced to an online database on biomarkers and open-source binding affinity resources. The material can be seamlessly integrated into the existing coursework by expanding discussions on binding kinetics and equilibrium.

Item Type: Journal Article
Publication: Journal of Chemical Education
Publisher: American Chemical Society
Additional Information: The copyright for this article belongs to American Chemical Society.
Keywords: Binding Kinetics; Computer Aided Learning; Interdisciplinary; Molecular Transport; Quantitative Analysis; Rate Law; Upper-Division Undergraduate
Department/Centre: Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited: 04 Nov 2022 09:39
Last Modified: 04 Nov 2022 09:39
URI: https://eprints.iisc.ac.in/id/eprint/77775

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