Fe-Doped MoS2Nanozyme for Antibacterial Activity and Detoxification of Mustard Gas Simulant

Ali, SR and De, M (2022) Fe-Doped MoS2Nanozyme for Antibacterial Activity and Detoxification of Mustard Gas Simulant. In: ACS Applied Materials and Interfaces, 14 (38). pp. 42940-42949.

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Abstract

The peroxidase-like catalytic activity of various nanozymes was extensively applied in various fields. In this study, we have demonstrated the preparation of Fe-doped MoS2 (Fe@MoS2) nanomaterials with enhanced peroxidase-like activity of MoS2 in a co-catalytic pathway. In view of Fenton reaction, the peroxidase-like Fe@MoS2 nanozyme prompted the decomposition of hydrogen peroxide (H2O2) to a reactive hydroxyl radical (·OH). The efficient decomposition of H2O2 in the presence of Fe@MoS2 has been employed toward the antibacterial activity and detoxification of mustard gas simulant. The combined effect of Fe@MoS2 and H2O2 showed remarkable antibacterial activity against the drug-resistant bacterial strain methicillin-resistant Staphylococcus aureus and Escherichia coli with the use of minimal concentration of H2O2. Fe@MoS2 was further applied for the detoxification of the chemical warfare agent sulfur mustard simulant, 2-chloroethyl ethyl sulfide, by selective conversion to the nontoxic sulfoxide. This work demonstrates the development of a hybrid nanozyme and its environmental remediation from harmful chemicals to microbes.

Item Type:	Journal Article
Publication:	ACS Applied Materials and Interfaces
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society.
Keywords:	Catalyst activity; Chemical warfare; Detoxification; Escherichia coli; Iron compounds; Layered semiconductors; Molybdenum compounds; Oxidation, Anti-bacterial activity; Catalytic pathways; Efficient decomposition; Fe-doped; Fe-doped MoS2; Fenton reactions; Hydroxyl radicals; Mustard Gas; Nanozyme; Peroxidase-like activities, Sulfur compounds, antiinfective agent; chemical warfare agent; hydrogen peroxide; hydroxyl radical; molybdenum; mustard gas; peroxidase; sulfoxide, chemistry; Escherichia coli; methicillin resistant Staphylococcus aureus, Anti-Bacterial Agents; Chemical Warfare Agents; Escherichia coli; Hydrogen Peroxide; Hydroxyl Radical; Methicillin-Resistant Staphylococcus aureus; Molybdenum; Mustard Gas; Peroxidase; Peroxidases; Sulfoxides
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	31 Oct 2022 08:46
Last Modified:	31 Oct 2022 08:46
URI:	https://eprints.iisc.ac.in/id/eprint/77637

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