Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans

Forst, CV and Martin-Sancho, L and Tripathi, S and Wang, G and Dos Anjos Borges, LG and Wang, M and Geber, A and Lashua, L and Ding, T and Zhou, X and Carter, CE and Metreveli, G and Rodriguez-Frandsen, A and Urbanowski, MD and White, KM and Stein, DA and Moulton, H and Chanda, SK and Pache, L and Shaw, ML and Ross, TM and Ghedin, E and García-Sastre, A and Zhang, B (2022) Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans. In: Science advances, 8 (40). eabm5859.

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Abstract

Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-specific molecular responses, we perform a comparative study of transcriptomic data derived from blood cells, primary epithelial cells, and lung tissues collected from IAV-infected humans, ferrets, and mice. The molecular responses in the human host have unique functions such as antigen processing that are not observed in mice or ferrets. Highly conserved gene coexpression modules across the three species are enriched for IAV infection-induced pathways including cell cycle and interferon (IFN) signaling. TDRD7 is predicted as an IFN-inducible host factor that is up-regulated upon IAV infection in the three species. TDRD7 is required for antiviral IFN response, potentially modulating IFN signaling via the JAK/STAT/IRF9 pathway. Identification of the common and species-specific molecular signatures, networks, and regulators of IAV infection provides insights into host-defense mechanisms and will facilitate the development of novel therapeutic interventions against IAV infection.

Item Type:	Journal Article
Publication:	Science advances
Publisher:	NLM (Medline)
Additional Information:	The copyright for this article belongs to American Association for the Advancement of Science.
Keywords:	antivirus agent; interferon; ribonucleoprotein; Tdrd7 protein, human, animal; communicable disease; genetics; human; influenza; Influenza A virus; metabolism; mouse; Mustela putorius furo; orthomyxovirus infection; physiology, Animals; Antiviral Agents; Communicable Diseases; Ferrets; Humans; Influenza A virus; Influenza, Human; Interferons; Mice; Orthomyxoviridae Infections; Ribonucleoproteins
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	28 Oct 2022 07:44
Last Modified:	28 Oct 2022 07:44
URI:	https://eprints.iisc.ac.in/id/eprint/77630

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