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Moving from empirical to rational vaccine design in the ‘Omics’ era

Sharma, M and Krammer, F and García-Sastre, A and Tripathi, S (2019) Moving from empirical to rational vaccine design in the ‘Omics’ era. In: Vaccines, 7 (3).

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Official URL: https://doi.org/10.3390/vaccines7030089

Abstract

An ideal vaccine provides long lasting protection against a pathogen by eliciting a well-rounded immune response which engages both innate and adaptive immunity. However, we have a limited understanding of how components of innate immunity, antibody and cell-mediated adaptive immunity interact and function together at a systems level. With advances in high-throughput ‘Omics’ methodologies it has become possible to capture global changes in the host, at a cellular and molecular level, that are induced by vaccination and infection. Analysis of these datasets has shown the promise of discovering mechanisms behind vaccine mediated protection, immunological memory, adverse effects as well as development of more efficient antigens and adjuvants. In this review, we will discuss how systems vaccinology takes advantage of new technology platforms and big data analysis, to enable the rational development of better vaccines.

Item Type: Journal Article
Publication: Vaccines
Publisher: MDPI AG
Additional Information: The copyright for this article belongs to the Authors.
Keywords: B lymphocyte antigen; chemokine receptor CCR4 antagonist; DNA vaccine; glycerophospholipid; HLA DQB1 antigen; immunological adjuvant; influenza vaccine; inositol phosphate; interferon; Meningococcus vaccine; mifamurtide; pathogen associated molecular pattern; sterol regulatory element binding protein 1; toll like receptor; vaccine; virus vaccine; virus vector, 2009 H1N1 influenza; antibody response; CD8+ T lymphocyte; dendritic cell; drug design; flow cytometry; gene expression profiling; human; immune response; immunogenicity; innate immunity; major histocompatibility complex; nonhuman; omics; quantitative trait locus; Review; seasonal influenza; transcriptomics
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Biological Sciences > Centre for Infectious Disease Research
Date Deposited: 13 Oct 2022 05:45
Last Modified: 13 Oct 2022 05:45
URI: https://eprints.iisc.ac.in/id/eprint/77360

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