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Claudins in the brain: Unconventional functions in neurons

Tikiyani, V and Babu, K (2019) Claudins in the brain: Unconventional functions in neurons. In: Traffic, 20 (11). pp. 807-814.

tra_20-11_807-814_2019.pdf - Published Version

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Official URL: https://doi.org/10.1111/tra.12685


Bonafide claudin proteins are functional and structural components of tight junctions and are largely responsible for barrier formation across epithelial and endothelial membranes. However, current advances in the understanding of claudin biology have revealed their unexpected functions in the brain. Apart from maintaining blood-brain barriers in the brain, other functions of claudins in neurons and at synapses have been largely elusive and are just coming to light. In this review, we summarize the functions of claudins in the brain and their association in neuronal diseases. Further, we go on to cover some recent studies that show that claudins play signaling functions in neurons by regulating trafficking of postsynaptic receptors and controlling dendritic morphogenesis in the model organism Caenorhabditis elegans.

Item Type: Journal Article
Publication: Traffic
Publisher: Blackwell Munksgaard
Additional Information: The copyright for this article belongs to the Authors.
Keywords: acetylcholine receptor 16; acetylcholine receptor alpha7; AMPA receptor; cholinergic receptor; claudin; HIC 1 protein; hypersensitive to pore forming toxin 30; levamisole sensitive acetylcholine receptor; postsynaptic receptor; protein; stargazin; unclassified drug; claudin, brain; Caenorhabditis elegans; dendritic cell; epithelium; human; morphogenesis; nerve cell; nervous system; nonhuman; priority journal; protein function; protein localization; Review; signal transduction; synaptic membrane; animal; brain; metabolism; nerve cell; neurologic disease, Animals; Brain; Claudins; Humans; Nervous System Diseases; Neurons
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Date Deposited: 19 Oct 2022 08:32
Last Modified: 19 Oct 2022 08:32
URI: https://eprints.iisc.ac.in/id/eprint/77333

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