Spontaneous formation and growth kinetics of lipid nanotubules induced by passive nanoparticles

Chelladurai, R and Debnath, K and Jana, NR and Basu, JK (2022) Spontaneous formation and growth kinetics of lipid nanotubules induced by passive nanoparticles. In: Soft Matter .

PDF soft_matter_2022.pdf - Published Version Restricted to Registered users only Download (3MB) | Request a copy

Abstract

Lipid nanotubules (LNTs) are conduits that form on the membranes of cells and organelles, and they are ubiquitous in all forms of life from archaea and bacteria to plants and mammals. The formation, shape and dynamics of these LNTs are critical for cellular functions, supporting the transport of myriad cellular cargoes as well as communication within and between cells, and they are also widely believed to be responsible for exploitation of host cells by pathogens for the spread of infection and diseases. In vitro kinetic control of LNT formation can considerably enhance the scope of utilization of these structures for disease control and therapy. Here we report a new paradigm for spontaneous lipid nanotubulation, capturing the dynamical regimes of growth, stabilization and retraction of the tubes through the binding of synthetic nanoparticles on supported lipid bilayers (SLBs). The tubulation is determined by the spontaneous binding-unbinding of nanoparticles on the LNTs. The presented methodology could be used to rectify malfunctioning cellular tubules or to prevent the pathogenic spread of diseases through inhibition of cell-to-cell nanotubule formation.

Item Type:	Journal Article
Publication:	Soft Matter
Publisher:	Royal Society of Chemistry
Additional Information:	The copyright for this article belongs to Royal Society of Chemistry.
Keywords:	Cells; Cytology; Growth kinetics; Lipid bilayers; Mammals; Nanoparticles, Archaeon; Cellular function; Cellulars; Host cells; In-vitro; Kinetic control; Nanotubules; Spontaneous formation; Spontaneous growth; Vitro kinetics, Disease control
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	12 Oct 2022 11:49
Last Modified:	12 Oct 2022 11:49
URI:	https://eprints.iisc.ac.in/id/eprint/77325

Actions (login required)

View Item