Antimicrobial Activity of Silver Nanoparticles Loaded Biomimetic Isomeric Short Lipopeptide Nanostructures

Kesharwani, K and Singh, R and Tripathi, SK and Kaul, G and Akhir, A and Saxena, D and Kumar, V and Mishra, NK and Chopra, S and Joshi, KB (2022) Antimicrobial Activity of Silver Nanoparticles Loaded Biomimetic Isomeric Short Lipopeptide Nanostructures. In: ChemistrySelect, 7 (35).

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Abstract

Lipopeptide-inspired lipidation of two short tripeptides, Phe-Tyr-β-Ala and Tyr-Phe-β-Ala leads to a pair of constitutional isomers of short peptide amphiphile (sPA). These two molecules were able to mimic lipopeptides properties and therefore could be used as potential drug delivery vehicles up to target sites. Further, these isomeric peptide amphiphiles were able to synthesize stable silver nanoparticles (AgNPs) in presence of sunlight without using any reducing agents. Interestingly, the presence of AgNPs significantly controls the secondary structures of these two isomeric sPAs and hence their self-assembly. Therefore, such AgNPs-sPA nanostructures are further used to develop antibacterial materials. Various microscopy and spectroscopy techniques were used to characterize these nanostructures. The antibacterial analysis demonstrated that owing to high biocompatibility and less cytotoxicity, designed sPA exhibited great potential in locally addressing bacterial infections. Thus, such a strategic design of lipidated tripeptide fragments can be tuned for potential therapeutic value for future applications.

Item Type:	Journal Article
Publication:	ChemistrySelect
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc.
Keywords:	Antibacterial biomaterial 1; Drug Delivery Agent 3; Isomeric short Peptide Amphiphiles 5; Self-assembly 4; Silver Nanoparticles 2
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	08 Oct 2022 04:05
Last Modified:	08 Oct 2022 04:05
URI:	https://eprints.iisc.ac.in/id/eprint/77287

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