Understanding the anomaly of cis–trans isomerism in Pro-His sequence

Gupta, SK and Banerjee, S and Prabhakaran, EN (2022) Understanding the anomaly of cis–trans isomerism in Pro-His sequence. In: Bioorganic and Medicinal Chemistry Letters, 76 .

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Abstract

The anomalous absence of cisPro stabilizing CαHαXaa···πAro interactions at Xaa-Pro-Aro exclusively when Aro is His, is understood by NMR structural analyses of model peptides, as due to i → i backbone-side chain C6 H-bond that forms uniquely when Aro is His, which significantly decreases its χ1-g- population essential for CαHαXaa···πAro formation. © 2022 Elsevier Ltd

Item Type:	Journal Article
Publication:	Bioorganic and Medicinal Chemistry Letters
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd.
Keywords:	Understanding the anomaly of cis–trans isomerism in Pro-His sequence
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	13 Oct 2022 05:32
Last Modified:	13 Oct 2022 05:32
URI:	https://eprints.iisc.ac.in/id/eprint/77280

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