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A flexible implantable microelectrode array for recording electrocorticography signals from rodents

Chatterjee, S and Sakorikar, T and Bs, A and Joshi, RK and Sikaria, A and Jayachandra, M and Vikas, V and Pandya, HJ (2022) A flexible implantable microelectrode array for recording electrocorticography signals from rodents. In: Biomedical Microdevices, 24 (4).

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Official URL: https://doi.org/10.1007/s10544-022-00632-0


Electrocorticography signals, the intracranial recording of electrical signatures of the brain, are recorded by non-penetrating planar electrode arrays placed on the cortical surface. Flexible electrode arrays minimize the tissue damage upon implantation. This work shows the design and development of a 32-channel flexible microelectrode array to record electrocorticography signals from the rat's brain. The array was fabricated on a biocompatible flexible polyimide substrate. A titanium/gold layer was patterned as electrodes, and a thin polyimide layer was used for insulation. The fabricated microelectrode array was mounted on the exposed somatosensory cortex of the right hemisphere of a rat after craniotomy and incision of the dura. The signals were recorded using OpenBCI Cyton Daisy Biosensing Boards. The array faithfully recorded the baseline electrocorticography signals, the induced epileptic activities after applying a convulsant, and the recovered baseline signals after applying an antiepileptic drug. The signals recorded by such fabricated microelectrode array from anesthetized rats demonstrate its potential to monitor electrical signatures corresponding to epilepsy. Finally, the time–frequency analyses highlight the difference in spatiotemporal features of baseline and evoked epileptic discharges.

Item Type: Journal Article
Publication: Biomedical Microdevices
Publisher: Springer
Additional Information: The copyright for this article belongs to Springer.
Keywords: Biocompatibility; Brain; Electric discharges; Implants (surgical); Microelectrodes; Polyimides, Biopotential acquisition; Biopotentials; Electrical signatures; Electrocorticography signal; Epileptic activity; Flexible microelectrode arrays; Implantable devices; Implantable microelectrode arrays; Microelectrodes arrays; Planar electrode, Rats
Department/Centre: Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology)
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 13 Oct 2022 04:58
Last Modified: 13 Oct 2022 04:58
URI: https://eprints.iisc.ac.in/id/eprint/77273

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