From structure and dynamics to biomolecular functions: The ubiquitous role of solvent in biology

Mondal, S and Bagchi, B (2022) From structure and dynamics to biomolecular functions: The ubiquitous role of solvent in biology. In: Current Opinion in Structural Biology, 77 .

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Abstract

Biological activity requires a solvent that can provide a suitable environment, which satisfies the twin need for stability and the ability to change. Among all the solvents water plays the most important role. We review, analyze, and comment on recent works on the structure and dynamics of water around biomolecules and their role in specific biological functions. While studies in the past have focused on understanding the biomolecule–water interactions through a hydration layer; recently the attention has shifted towards understanding functions at a molecular level. Such a microscopic understanding clearly requires elucidation of detailed dynamical processes where solvent molecules play an important role. Finally, we comment on the advances made in understanding the role of water inside a biological cell.

Item Type:	Journal Article
Publication:	Current Opinion in Structural Biology
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd.
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	12 Oct 2022 04:32
Last Modified:	12 Oct 2022 04:32
URI:	https://eprints.iisc.ac.in/id/eprint/77268

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