Ramakrishnan, R and Singh, AK and Singh, S and Chakravortty, D and Das, D (2022) Enzymatic dispersion of biofilms: An emerging biocatalytic avenue to combat biofilm-mediated microbial infections. In: Journal of Biological Chemistry, 298 (9).
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Abstract
Drug resistance by pathogenic microbes has emerged as a matter of great concern to mankind. Microorganisms such as bacteria and fungi employ multiple defense mechanisms against drugs and the host immune system. A major line of microbial defense is the biofilm, which comprises extracellular polymeric substances that are produced by the population of microorganisms. Around 80 of chronic bacterial infections are associated with biofilms. The presence of biofilms can increase the necessity of doses of certain antibiotics up to 1000-fold to combat infection. Thus, there is an urgent need for strategies to eradicate biofilms. Although a few physicochemical methods have been developed to prevent and treat biofilms, these methods have poor efficacy and biocompatibility. In this review, we discuss the existing strategies to combat biofilms and their challenges. Subsequently, we spotlight the potential of enzymes, in particular, polysaccharide degrading enzymes, for biofilm dispersion, which might lead to facile antimicrobial treatment of biofilm-associated infections.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Biological Chemistry |
| Publisher: | American Society for Biochemistry and Molecular Biology Inc. |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | Bacteria; Biocompatibility; Biodegradation; Dispersions; Hydrolases; Network security, Bacterial infections; Biofilm dispersion; Defence mechanisms; Drug-resistance; Extracellular; Glycoside hydrolases; Microbial infections; Pathogenic microbes; Physicochemical methods; Polymeric substance, Biofilms |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology Division of Chemical Sciences > Inorganic & Physical Chemistry |
| Date Deposited: | 08 Oct 2022 04:00 |
| Last Modified: | 08 Oct 2022 04:00 |
| URI: | https://eprints.iisc.ac.in/id/eprint/77226 |
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