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Extracellular matrix as a driver for intratumoral heterogeneity

Pally, D and Goutham, S and Bhat, R (2022) Extracellular matrix as a driver for intratumoral heterogeneity. In: Physical Biology, 19 (4).

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Official URL: https://doi.org/10.1088/1478-3975/ac6eb0


The architecture of an organ is built through interactions between its native cells and its connective tissue consisting of stromal cells and the extracellular matrix (ECM). Upon transformation through tumorigenesis, such interactions are disrupted and replaced by a new set of intercommunications between malignantly transformed parenchyma, an altered stromal cell population, and a remodeled ECM. In this perspective, we propose that the intratumoral heterogeneity of cancer cell phenotypes is an emergent property of such reciprocal intercommunications, both biochemical and mechanical-physical, which engender and amplify the diversity of cell behavioral traits. An attempt to assimilate such findings within a framework of phenotypic plasticity furthers our understanding of cancer progression.

Item Type: Journal Article
Publication: Physical Biology
Publisher: Institute of Physics
Additional Information: The copyright for this article belongs to the Institute of Physics.
Keywords: extracellular matrix; genetics; human; neoplasm, Extracellular Matrix; Humans; Neoplasms
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 27 Sep 2022 07:32
Last Modified: 27 Sep 2022 07:32
URI: https://eprints.iisc.ac.in/id/eprint/77210

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