Lack of Correlation between Landscape Geometry and Transition Rates

Jia, W and Duddu, AS and Jolly, MK and Levine, H (2022) Lack of Correlation between Landscape Geometry and Transition Rates. In: Journal of Physical Chemistry B, 126 (30). pp. 5613-5618.

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Abstract

Biological cells can exist in a variety of distinct phenotypes, determined by the steady-state solutions of genetic networks governing their cell fate. A popular way of representing these states relies on the creation of landscape related to the relative occupation of these states. It is often assumed that this landscape offers direct information regarding the state-to-state transition rates, suggesting that these are related to barrier heights separating landscape minima. Here, we study a toggle triad network exhibiting multistability and directly demonstrate the lack of any direct correlation between properties of the landscape and corresponding transition rates.

Item Type:	Journal Article
Publication:	Journal of Physical Chemistry B
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to the American Chemical Society.
Keywords:	Barrier heights; Biological cells; Cell-fate; Genetic networks; Geometry rate; Multistability; Property; State-to-state transition; Steady state solution; Transition rates, cell differentiation; gene regulatory network, Cell Differentiation; Gene Regulatory Networks
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	06 Oct 2022 09:52
Last Modified:	06 Oct 2022 09:52
URI:	https://eprints.iisc.ac.in/id/eprint/77191

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