Studies of in vitro antioxidant and anti-inflammatory activities of gold nanoparticles biosynthesised from a medicinal plant, Commiphora wightii

Uzma, M and Prasad, DR and Sunayana, N and Raghavendra, VB and Shilpashree, HP (2022) Studies of in vitro antioxidant and anti-inflammatory activities of gold nanoparticles biosynthesised from a medicinal plant, Commiphora wightii. In: Materials Technology, 37 (9). pp. 915-925.

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Abstract

Green synthesis of nanoparticles is one of the recent trends nowadays owing to its reduced toxic effects. Our study is aimed at evaluating the biological potential viz., antioxidant and anti-inflammatory properties of gold nanoparticles (AuNPs) biosynthesised using an aqueous extract of Commiphora wightii. The AuNPs synthesis was preliminarily confirmed by colour change from yellow to purple. Further, AuNPs synthesis was optimised at different ratio, pH and temperature. AuNPs were characterised using spectroscopic and microscopic techniques. FTIR analysis confirmed role of biomolecules in reduction and stabilisation of AuNPs. TEM analysis revealed polydispersed nanoparticles with an average size of 20.2 ± 6.6 nm. In vitroantioxidant activity of AuNPs were evaluated using DPPH, ABTS and H2O2 assays. The AuNPs showed significant radical scavenging ability. In vitro anti-inflammatory activity was studied for inhibition of albumin denaturation, Trypsin, LOX, and hyaluronidase enzymes. The AuNPs exhibited good activity as potent anti-inflammatory agents. Further in vivo studies are needed to explore them as good therapeutic agents. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

Item Type:	Journal Article
Publication:	Materials Technology
Publisher:	Taylor and Francis Ltd.
Additional Information:	The copyright for this article belongs to the Taylor and Francis Ltd.
Keywords:	Antioxidants; Drug products; Enzyme inhibition; Fiber optic sensors; Gold nanoparticles; Green Synthesis; Hydrogen peroxide; Metal nanoparticles; Molecular biology; Plant extracts, Anti-inflammatories; Anti-inflammatory activity; Anti-inflammatory agents; Biological potential; Medicinal plants; Radical scavenging; Spectroscopic and microscopic techniques; Therapeutic agents, Gold compounds
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	06 Oct 2022 09:19
Last Modified:	06 Oct 2022 09:19
URI:	https://eprints.iisc.ac.in/id/eprint/77163

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