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Genetic diversity of Plasmodium falciparum isolates in Nigeria. A review

Opute, AO and Akinkunmi, JA and Funsho, AO and Obaniyi, AK and Anifowoshe, AT (2022) Genetic diversity of Plasmodium falciparum isolates in Nigeria. A review. In: Egyptian Journal of Medical Human Genetics, 23 (1).

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Official URL: https://doi.org/10.1186/s43042-022-00340-7


Background: The complexity of infection in malaria-endemic areas is exacerbated by the presence of genetically diverse Plasmodium falciparum strains. There is a risk that more virulent or drug-resistant versions of the disease may arise. Therefore, we reviewed most reported molecular markers that have been detailed to date in Nigeria. Main body of the abstract: In this review, we have summarized the genetic diversity of P. falciparum in Nigeria using the two well-reported genes (msp1 and msp2) as genetic diversity biomarkers. The review includes the findings obtained from research conducted in all major geopolitical regions of the country. We found that MSP-2 infection complexity is generally moderate to high in the North-central region. However, in the South-West, there were several regions where the multiplicity of infection (MOI) was either low or extremely high. Conclusion: Understanding how Nigeria's malaria situation fits into various reports on P. falciparum genetic variation can improve treatment and immunization options. This review will be helpful for future treatment strategies that would be tailored to the specific needs of Nigeria's malaria-endemic populations. © 2022, The Author(s).

Item Type: Journal Article
Publication: Egyptian Journal of Medical Human Genetics
Publisher: Springer Science and Business Media Deutschland GmbH
Additional Information: The copyright for this article belongs to the Authors.
Keywords: Genetic diversity; Malaria; MSP1 & 2; Nigeria; Plasmodium falciparum
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 05 Oct 2022 04:39
Last Modified: 05 Oct 2022 04:39
URI: https://eprints.iisc.ac.in/id/eprint/77011

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