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Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium

Bagha, T and Kamal, AM and Pal, UM and Mohan Rao, PS and Pandya, HJ (2022) Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium. In: Journal of Biomedical Optics, 27 (5).

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Official URL: https://doi.org/10.1117/1.JBO.27.5.055001


Significance: Optical polarimetry is an emerging modality that effectively quantifies the bulk optical properties that correlate with the anisotropic structural properties of cardiac tissues. We demonstrate the application of a polarimetric tool for characterizing healthy and fibrotic human myocardial tissues efficiently with a high degree of accuracy. Aim: The study was aimed to characterize the myocardial tissues from the left ventricle and right ventricle of N = 7 control and N = 10 diseased subjects. The diseased subjects were composed of two groups: N = 7 with rheumatic heart disease (RHD) and N = 3 with myxomatous valve (MV) disease. Approach: A portable, affordable, and accurate linear polarization-based diagnostic tool is developed to measure the degree of linear polarization (DOLP) of the myocardial tissues while working at a wavelength of 850 nm. Results: The sensitivity, specificity, and accuracy of the polarimetric tool in distinguishing the control group from the RHD group were found to be 73.33, 76.92, and 75, respectively, and from the MV group were 91.6, 62.5, and 80, respectively, which demonstrates the efficacy of the polarimetric tool to distinguish the healthy myocardial tissues from diseased tissues. Conclusions: We have successfully developed a polarimetric tool that can aid cardiologists in characterizing the myocardial tissues in conjunction with endomyocardial biopsy. This work should be followed up with experiments on a large cohort of control and diseased subjects. We intend to create and develop a probe to quantify the DOLP of in vivo heart tissue during surgery. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Item Type: Journal Article
Publication: Journal of Biomedical Optics
Publisher: SPIE
Additional Information: The copyright for this article belongs to the Authors.
Keywords: Cardiology; Diagnosis; Diseases; Ellipsometry; Heart; Histology; Optical properties; Polarization; Tissue, Cardiac fibrose; Cardiac tissues; Degree of linear polarization; High degree of accuracy; Left ventricles; Myocardial tissue; Myxomatous valve; Optical polarimetry; Rheumatic heart disease; Ventricular myocardium, Polarimeters, biopsy; cardiac muscle; diagnostic imaging; heart; heart ventricle; human; spectroscopy, Biopsy; Heart; Heart Ventricles; Humans; Myocardium; Spectrum Analysis
Department/Centre: Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology)
Date Deposited: 29 Sep 2022 06:16
Last Modified: 29 Sep 2022 06:16
URI: https://eprints.iisc.ac.in/id/eprint/76823

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