Bhunia, S and Saha, P and Moitra, P and Addicoat, MA and Bhattacharya, S (2022) Efficacious and sustained release of an anticancer drug mitoxantrone from new covalent organic frameworks using protein corona. In: Chemical Science, 13 (26). pp. 7920-7932.
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Abstract
Solid porous and crystalline covalent organic frameworks (COFs) are characterized by their higher specific BET surface areas and functional pore walls, which allow the adsorption of various bioactive molecules inside the porous lattices. We have introduced a perylene-based COF, PER@PDA-COF-1, which acts as an effective porous volumetric reservoir for an anticancer drug, mitoxantrone (MXT). The drug-loaded COF (MXT-PER@PDA-COF-1) exhibited zero cellular release of MXT towards cancer cells, which can be attributed to the strong intercalation between the anthracene-dione motif of the drug and the perylene-based COF backbone. Here, we have introduced a strategy involving the serum-albumin-triggered intracellular release of mitoxantrone from MXT-PER@PDA-COF-1. The serum albumin acts as an exfoliating agent and as a colloidal stabilizer in PBS medium (pH = 7.4), rapidly forming a protein corona around the exfoliated COF crystallites and inducing the sustained release of MXT from the COF into tumorigenic cells.
| Item Type: | Journal Article |
|---|---|
| Publication: | Chemical Science |
| Publisher: | Royal Society of Chemistry |
| Additional Information: | The copyright for this article belongs to the Author. |
| Keywords: | Crystallites; Drug products; Polycyclic aromatic hydrocarbons; Proteins; Sols; Targeted drug delivery, Anticancer drug; BET surface area; Covalent organic frameworks; Mitoxantrone; Perylenes; Pore wall; Protein coronas; Serum albumin; Surface functional; Sustained release, Controlled drug delivery |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 16 Sep 2022 06:22 |
| Last Modified: | 16 Sep 2022 06:22 |
| URI: | https://eprints.iisc.ac.in/id/eprint/76535 |
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