ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases

Banerjee, U and Rao, P and Reddy, M and Hussain, M and Chunchanur, S and Ambica, R and Singh, A and Chandra, N (2022) A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases. In: Molecular Omics .

[img] PDF
a_9gene_biomaker_2022.pdf - Published Version
Restricted to Registered users only

Download (1MB)
Official URL: https://doi.org/10.1039/d2mo00100d


Confirmatory diagnosis of bacterial coinfections with COVID-19 is challenging due to the limited specificity of the widely used gold-standard culture sensitivity test despite clinical presentations. A misdiagnosis can either lead to increased health complications or overuse of antibiotics in COVID-19 patients. With a multi-step systems biology pipeline, we have identified a 9-gene biomarker panel from host blood that can identify bacterial coinfection in COVID-19 patients, even in culture-negative cases. We have also formulated a qPCR-based score that diagnoses bacterial coinfection with COVID-19 with the accuracy, specificity, and sensitivity of 0.93, 0.96, and 0.89, respectively. This gene signature and score can assist in the clinical decision-making process of necessary and timely prescription of antibiotics in suspected bacterial coinfection cases with COVID-19 and thereby help to reduce the associated morbidity and mortality. © 2022 The Royal Society of Chemistry.

Item Type: Journal Article
Publication: Molecular Omics
Publisher: Royal Society of Chemistry
Additional Information: The copyright for this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 06 Sep 2022 06:58
Last Modified: 06 Sep 2022 06:58
URI: https://eprints.iisc.ac.in/id/eprint/76467

Actions (login required)

View Item View Item