Heterosynthons, Solid Form Design and Enhanced Drug Bioavailability

Nangia, AK and Desiraju, GR (2022) Heterosynthons, Solid Form Design and Enhanced Drug Bioavailability. In: Angewandte Chemie - International Edition .

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Abstract

Starting from a molecular pharmacophore, which is a marker of drug action in medicinal molecules, we propose that the heterosynthon, a supramolecular synthon between unlike functional groups, plays an analogous role in the design and discovery of high bioavailability drugs. The heterosynthon could provide a more efficient and economical route to novel drugs.

Item Type:	Journal Article
Publication:	Angewandte Chemie - International Edition
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc
Keywords:	Biochemistry; Supramolecular chemistry, Co-crystals; Drug action; Drug discovery; Form design; Pharmaceutical development; Pharmacophores; Solid forms; Supramolecular synthons, Crystal engineering
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	14 Sep 2022 10:27
Last Modified:	14 Sep 2022 10:27
URI:	https://eprints.iisc.ac.in/id/eprint/76459

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