# Structure of cholest-5-en-3$\beta$-oxy-5-bromopentane by singlecrystal X-ray diffraction at 130 K

Ghosh, Yamuna Krishnan and Gopalanb, Srinivasa R and Kulkarni, GU and Bhattacharya, Santanu (2001) Structure of cholest-5-en-3$\beta$-oxy-5-bromopentane by singlecrystal X-ray diffraction at 130 K. In: Journal of Molecular Structure, 560 (1-3). pp. 345-355.

 PDF structure_of_cholest.........pdf Restricted to Registered users only Download (149kB) | Request a copy

## Abstract

Cholest $5-en-3\beta-oxy-5$ bromopentane (1) and cholest $5-en -3\beta-oxy-11$ bromoundecane (2), key precursors for the synthesis of novel cationic amphiphiles based on cholesterol, have been synthesized and characterized by $^1H-NMR$ spectroscopy and Xray crystallography. Thermal disorder and effect of length of the bromoalkyl segment on the crystal structure have been investigated. Possible molecular level explanation of the unusual alternating s-trans gauche conformation of the bromopentyl side chain of (1) has been presented.

Item Type: Journal Article Journal of Molecular Structure Elsevier Copyright of this article belongs to Elsevier. X-ray crystallography;Cholesteryl ether;Thermal disorder;Side-chain Division of Chemical Sciences > Organic Chemistry 15 Jun 2006 19 Sep 2010 04:29 http://eprints.iisc.ac.in/id/eprint/7641