Structure of cholest-5-en-3$\beta$-oxy-5-bromopentane by singlecrystal X-ray diffraction at 130 K

Ghosh, Yamuna Krishnan and Gopalanb, Srinivasa R and Kulkarni, GU and Bhattacharya, Santanu (2001) Structure of cholest-5-en-3$\beta$-oxy-5-bromopentane by singlecrystal X-ray diffraction at 130 K. In: Journal of Molecular Structure, 560 (1-3). pp. 345-355.

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Abstract

Cholest $5-en-3\beta-oxy-5$ bromopentane (1) and cholest $5-en -3\beta-oxy-11$ bromoundecane (2), key precursors for the synthesis of novel cationic amphiphiles based on cholesterol, have been synthesized and characterized by $^1H-NMR$ spectroscopy and Xray crystallography. Thermal disorder and effect of length of the bromoalkyl segment on the crystal structure have been investigated. Possible molecular level explanation of the unusual alternating s-trans gauche conformation of the bromopentyl side chain of (1) has been presented.

Item Type:	Journal Article
Publication:	Journal of Molecular Structure
Publisher:	Elsevier
Additional Information:	Copyright of this article belongs to Elsevier.
Keywords:	X-ray crystallography;Cholesteryl ether;Thermal disorder;Side-chain
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	15 Jun 2006
Last Modified:	19 Sep 2010 04:29
URI:	http://eprints.iisc.ac.in/id/eprint/7641

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