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Computational Study on the Dynamics of Mycobacterium Tuberculosis RNA Polymerase Assembly

Bheemireddy, S and Srinivasan, N (2022) Computational Study on the Dynamics of Mycobacterium Tuberculosis RNA Polymerase Assembly. [Book Chapter]

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Official URL: https://doi.org/10.1007/978-1-0716-2413-5_5


Gene regulation is an intricate phenomenon involving precise function of many macromolecular complexes. Molecular basis of this phenomenon is highly complex and cannot be fully understood using a single technique. Computational approaches can play a crucial role in overall understanding of functional and mechanistic features of a protein or an assembly. Large amounts of structural data pertaining to these complexes are publicly available. In this project, we took advantage of the availability of the structural information to unravel functional intricacies of Mycobacterium tuberculosis RNA polymerase upon interaction with RbpA. In this article, we discuss how the knowledge on protein structure and dynamics can be exploited to study function using various computational tools and resources. Overall, this article provides an overview of various computational methods which can be efficiently used to understand the role of any protein. We hope especially the nonexperts in the field could benefit from our article.

Item Type: Book Chapter
Publication: Methods in Molecular Biology
Series.: Methods in Molecular Biology
Publisher: Humana Press Inc.
Additional Information: The copyright for this article belongs to the Humana Press Inc.
Keywords: bacterial protein; DNA directed RNA polymerase, biology; genetics; metabolism; Mycobacterium tuberculosis; promoter region, Bacterial Proteins; Computational Biology; DNA-Directed RNA Polymerases; Mycobacterium tuberculosis; Promoter Regions, Genetic
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 31 Aug 2022 06:53
Last Modified: 31 Aug 2022 06:53
URI: https://eprints.iisc.ac.in/id/eprint/76291

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