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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E and Warren, HR and Mosen-Ansorena, D and Mifsud, B and Pazoki, R and Gao, H and Ntritsos, G and Dimou, N and Cabrera, CP and Karaman, I and Ng, FL and Evangelou, M and Witkowska, K and Tzanis, E and Hellwege, JN and Giri, A and Velez Edwards, DR and Sun, YV and Cho, K and Gaziano, JM and Wilson, PWF and Tsao, PS and Kovesdy, CP and Esko, T and Mägi, R and Milani, L and Almgren, P and Boutin, T and Debette, S and Ding, J and Giulianini, F and Holliday, EG and Jackson, AU and Li-Gao, R and Lin, W-Y and Luan, J and Mangino, M and Oldmeadow, C and Prins, BP and Qian, Y and Sargurupremraj, M and Shah, N and Surendran, P and ThÃriault, S and Verweij, N and Willems, SM and Zhao, J-H and Amouyel, P and Connell, J and de Mutsert, R and Doney, ASF and Farrall, M and Menni, C and Morris, AD and Noordam, R and ParÃ, G and Poulter, NR and Shields, DC and Stanton, A and Thom, S and Abecasis, G and Amin, N and Arking, DE and Ayers, KL and Barbieri, CM and Batini, C and Bis, JC and Blake, T and Bochud, M and Boehnke, M and Boerwinkle, E and Boomsma, DI and Bottinger, EP and Braund, PS and Brumat, M and Campbell, A and Campbell, H and Chakravarti, A and Chambers, JC and Chauhan, G and Ciullo, M and Cocca, M and Collins, F and Cordell, HJ and Davies, G and de Borst, MH and de Geus, EJ and Deary, IJ and Deelen, J and Del Greco M, F and Demirkale, CY and DÃrr, M and Ehret, GB and Elosua, R and Enroth, S and Erzurumluoglu, AM and Ferreira, T and FrÃ¥nberg, M and Franco, OH and Gandin, I and Gasparini, P and Giedraitis, V and Gieger, C and Girotto, G and Goel, A and Gow, AJ and Gudnason, V and Guo, X and Gyllensten, U and Hamsten, A and Harris, TB and Harris, SE and Hartman, CA and Havulinna, AS and Hicks, AA and Hofer, E and Hofman, A and Hottenga, J-J and Huffman, JE and Hwang, S-J and Ingelsson, E and James, A and Jansen, R and Jarvelin, M-R and Joehanes, R and Johansson, à and Johnson, AD and Joshi, PK and Jousilahti, P and Jukema, JW and Jula, A and KähÃnen, M and Kathiresan, S and Keavney, BD and Khaw, K-T and Knekt, P and Knight, J and Kolcic, I and Kooner, JS and Koskinen, S and Kristiansson, K and Kutalik, Z and Laan, M and Larson, M and Launer, LJ and Lehne, B and Lehtimäki, T and Liewald, DCM and Lin, L and Lind, L and Lindgren, CM and Liu, YM and Loos, RJF and Lopez, LM and Lu, Y and Lyytikäinen, L-P and Mahajan, A and Mamasoula, C and Marrugat, J and Marten, J and Milaneschi, Y and Morgan, A and Morris, AP and Morrison, AC and Munson, PJ and Nalls, MA and Nandakumar, P and Nelson, CP and Niiranen, T and Nolte, IM and Nutile, T and Oldehinkel, AJ and Oostra, BA and OâReilly, PF and Org, E and Padmanabhan, S and Palmas, W and Palotie, A and Pattie, A and Penninx, BWJH and Perola, M and Peters, A and Polasek, O and Pramstaller, PP and Nguyen, QT and Raitakari, OT and Ren, M and Rettig, R and Rice, K and Ridker, PM and Ried, JS and Riese, H and Ripatti, S and Robino, A and Rose, LM and Rotter, JI and Rudan, I and Ruggiero, D and Saba, Y and Sala, CF and Salomaa, V and Samani, NJ and Sarin, A-P and Schmidt, R and Schmidt, H and Shrine, N and Siscovick, D and Smith, AV and Snieder, H and Sõber, S and Sorice, R and Starr, JM and Stott, DJ and Strachan, DP and Strawbridge, RJ and SundstrÃm, J and Swertz, MA and Taylor, KD and Teumer, A and Tobin, MD and Tomaszewski, M and Toniolo, D and Traglia, M and Trompet, S and Tuomilehto, J and Tzourio, C and Uitterlinden, AG and Vaez, A and van der Most, PJ and van Duijn, CM and Vergnaud, A-C and Verwoert, GC and Vitart, V and Völker, U and Vollenweider, P and Vuckovic, D and Watkins, H and Wild, SH and Willemsen, G and Wilson, JF and Wright, AF and Yao, J and Zemunik, T and Zhang, W and Attia, JR and Butterworth, AS and Chasman, DI and Conen, D and Cucca, F and Danesh, J and Hayward, C and Howson, JMM and Laakso, M and Lakatta, EG and Langenberg, C and Melander, O and Mook-Kanamori, DO and Palmer, CNA and Risch, L and Scott, RA and Scott, RJ and Sever, P and Spector, TD and van der Harst, P and Wareham, NJ and Zeggini, E and Levy, D and Munroe, PB and Newton-Cheh, C and Brown, MJ and Metspalu, A and Hung, AM and OâDonnell, CJ and Edwards, TL and Psaty, BM and Tzoulaki, I and Barnes, MR and Wain, LV and Elliott, P and Caulfield, MJ (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. In: Nature Genetics, 50 (12). p. 1755.

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Official URL: https://doi.org/10.1038/s41588-018-0205-x


High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Item Type: Journal Article
Publication: Nature Genetics
Publisher: Nature Publishing Group
Additional Information: The copyright for this article belongs to the Author.
Keywords: article; blood pressure; genetic analysis; genetics; human; erratum; error
Department/Centre: Autonomous Societies / Centres > Centre for Brain Research
Date Deposited: 23 Aug 2022 06:19
Last Modified: 23 Aug 2022 06:23
URI: https://eprints.iisc.ac.in/id/eprint/76195

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