Molecular Origin of Spatiotemporal Heterogeneity in Biomembranes With Coexisting Liquid Phases: Insights From Topological Rearrangements and Lipid Packing Defects

Tripathy, M and Iyer, SS and Srivastava, A (2018) Molecular Origin of Spatiotemporal Heterogeneity in Biomembranes With Coexisting Liquid Phases: Insights From Topological Rearrangements and Lipid Packing Defects. [Book Chapter]

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Abstract

Lateral heterogeneities in biomembranes are physiologically important for various cellular functions. While the nature of structural heterogeneities is well studied, their molecular origin remains ambiguous. In this chapter, we discuss our recent investigations on lateral heterogeneity in model membranes with coexisting fluid phases. Using ideas from physics of amorphous material and glasses, we employ nonaffine deformation–based numerical characterization to distinguish between the liquid-ordered (Lo) and liquid-disordered (Ld) regions in model lipid bilayers. We are able to identify some nontrivial connections between the lipid-level topological rearrangements and the hydrophobic defects distributions in phase-separated membranes. The method provides a new framework to explore the molecular origin of spatial heterogeneity in biomembranes. The lipid-level deformation data, along with the nature of defects dynamics and their localization at the Lo–Ld interface, provide molecular-level insights into preferential binding of certain peptides at domain boundaries.

Item Type:	Book Chapter
Publication:	Advances in Biomembranes and Lipid Self-Assembly
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to the Elsevier Inc.
Keywords:	Biomembrane heterogeneities; Defect localization; Hydrophobic defects; Lipid membrane; Liquid-disordered phases; Liquid-ordered; Nonaffine deformation; Protein association; Topological rearrangements
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	27 Aug 2022 05:45
Last Modified:	27 Aug 2022 05:45
URI:	https://eprints.iisc.ac.in/id/eprint/76046

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