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Antioxidant activity of amine-based organoselenium compounds having intramolecular Se-Se bonds

Bhowmick, D and Mugesh, G (2018) Antioxidant activity of amine-based organoselenium compounds having intramolecular Se-Se bonds. In: Indian Journal of Heterocyclic Chemistry, 28 (1). pp. 43-50.

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Amine-based diselenides have been studied as synthetic mimics of the antioxidant enzyme glutathione peroxidase (GPx). In this study, a series of intramolecular diaryl diselenides were synthesized and studied for their antioxidant activity. A structure-activity correlation study reveals that these intramolecular diselenides are more active than the standard GPx mimetic ebselen, but the activity is significantly lower than that of the corresponding diselenides having intermolecular diselenide bonds. The crystal structure of a representative compound suggests that the poor activity is due to the absence of any strong Se-N interactions, which has been shown to play important roles in the catalytic activity. As the diselenide bonds are not activated for cleavage by thiols, the reduction of peroxides involves an initial reaction of the selenium center with peroxide during the catalytic cycle.

Item Type: Journal Article
Publication: Indian Journal of Heterocyclic Chemistry
Publisher: Connect Journal
Additional Information: The copyright for this article belongs to the Connect Journal.
Keywords: Antioxidant; Enzyme mimics; Glutathione; Intramolecular diselenide; Selenium
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 19 Aug 2022 06:15
Last Modified: 19 Aug 2022 06:15
URI: https://eprints.iisc.ac.in/id/eprint/76012

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