Pandey, P and Kaur, G and Babu, K (2022) Crosstalk between neurons and glia through G-protein coupled receptors: Insights from Caenorhabditis elegans. [Book Chapter]
Full text not available from this repository.Abstract
The past decades have witnessed a dogmatic shift from glia as supporting cells in the nervous system to their active roles in neurocentric functions. Neurons and glia communicate and show bidirectional responses through tripartite synapses. Studies across species indicate that neurotransmitters released by neurons are perceived by glial receptors, which allow for gliotransmitter release. These gliotransmitters can result in activation of neurons via neuronal GPCR receptors. However, studies of these molecular interactions are in their infancy. Caenorhabditis elegans has a conserved neuron-glia architectural repertoire with molecular and functional resemblance to mammals. Further, glia in C. elegans can be manipulated through ablation and mutations allowing for deciphering of glial dependent processes in vivo at single glial resolutions. Here, we will review recent findings from vertebrate and invertebrate organisms with a focus on how C. elegans can be used to advance our understanding of neuron-glia interactions through GPCRs.
| Item Type: | Book Chapter |
|---|---|
| Publication: | Progress in Molecular Biology and Translational Science |
| Publisher: | Elsevier B.V. |
| Additional Information: | The copyright for this article belongs to the Elsevier B.V. |
| Keywords: | C. elegans; Glia; GPCRs; Neurotransmitters |
| Department/Centre: | Division of Biological Sciences > Centre for Neuroscience |
| Date Deposited: | 10 Aug 2022 06:12 |
| Last Modified: | 10 Aug 2022 06:12 |
| URI: | https://eprints.iisc.ac.in/id/eprint/75792 |
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