Knowing right from wrong: Quality control of ribosome biogenesis in Eubacteria

Shetty, S (2018) Knowing right from wrong: Quality control of ribosome biogenesis in Eubacteria. In: Proceedings of the Indian National Science Academy, 84 (3). pp. 599-609.

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Abstract

Ribosomes are amongst the largest molecular machines in any living cell, which consist of three ribosomal RNAs (rRNAs) over 50 ribosomal proteins (r-proteins). In bacteria they have a small subunit (30S) and a large subunit (50S) which together form a functional 70S ribosome, which translates the information in a messenger RNA (mRNA) into a polypeptide sequence. Translation occurs in multiple steps such as initiation, elongation, termination and recycling. The fidelity of these steps depends on the faithful assembly of the ribosome itself. The synthesis of ribosomes involves various processes such as folding and processing of rRNA, ordered loading of ribosomal proteins and modification of various critical residues in them. For accuracy of protein synthesis, a cell must ensure that the immature particles are kept away from participating in active translation. And, once the ribosomes have been assembled, the cells must have a quality check to ensure the accuracy of assembled particles. Defect in any of these processes will result in the occurrence of defective ribosomes in translating pool, which in turn may lead to production of mis-translated proteins. In humans, genetic disorders of ribosomopathies occur because of deficiencies in ribosome biogenesis and quality control. Thus, it is crucial to understand the hitherto obscure mechanisms of quality control of ribosome biogenesis. This review is an attempt to provide an overview of our understanding of quality control mechanisms in ribosome biogenesis of prokaryotes.

Item Type:	Journal Article
Publication:	Proceedings of the Indian National Science Academy
Publisher:	Indian National Science Academy
Additional Information:	The copyright for this article belongs to the Indian National Science Academy.
Keywords:	Bacteria; Biosynthesis; Defects; Nucleic acids; Proteins; Quality assurance; RNA, Biogenesis; Genetic disorders; Messenger RNAs (mRNA); Molecular machines; Protein synthesis; Ribosomal proteins; Ribosome biogenesis; Translated proteins, Quality control
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	05 Aug 2022 11:10
Last Modified:	05 Aug 2022 11:10
URI:	https://eprints.iisc.ac.in/id/eprint/75394

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