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An Unusual Two-Step Hydrolysis of Nerve Agents by a Nanozyme

Khulbe, K and Roy, P and Radhakrishnan, A and Mugesh, G (2018) An Unusual Two-Step Hydrolysis of Nerve Agents by a Nanozyme. In: ChemCatChem, 10 (21). pp. 4840-4845.

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Official URL: https://doi.org/10.1002/cctc.201801220


Organophosphate-based nerve agents irreversibly inhibit acetylcholinesterase enzyme, leading to respiratory failure, paralysis and death. Several organophosphorus hydrolases are capable of degrading nerve agents including pesticides and insecticides. Development of stable artificial enzymes capable of hydrolysing nerve agents is important for the degradation of environmentally toxic organophosphates. Herein, we describe a Zr-incorporated CeO2 nanocatalyst that can be used for an efficient capture and hydrolysis of nerve agents such as methyl paraoxon to less toxic monoesters. This unusual sequential degradation pathway involves a covalently linked nanocatalyst-phosphodiester intermediate.

Item Type: Journal Article
Publication: ChemCatChem
Publisher: Wiley Blackwell
Additional Information: The copyright for this article belongs to Wiley Blackwell.
Keywords: Catalysis; Cerium oxide; Hydrolases; Nanocatalysts; Zirconium compounds, Acetylcholinesterase enzymes; Artificial enzymes; Enzyme models; nanozymes; Nerve agents; Phosphotriesterases; Respiratory failure; Sequential degradation, Hydrolysis
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 02 Aug 2022 11:55
Last Modified: 02 Aug 2022 11:55
URI: https://eprints.iisc.ac.in/id/eprint/75161

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