Interaction of synthetic analogs of distamycin with DNA Role of the conjugated N-methylpyrrole system in specificity of binding

Parrack, Pradipkumar and Dasgupta, Dipak and Ayyer, Jayalekshmy and Sasisekharan, V (1987) Interaction of synthetic analogs of distamycin with DNA Role of the conjugated N-methylpyrrole system in specificity of binding. In: FEBS Letters, 212 (2). pp. 297-301.

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Abstract

Interaction of two synthetic analogs of distamycin (Dst), PPA and PAP, containing a saturated β-alanine moiety replacing one N-methylpyrrole ring, with different polynucleotides and natural DNAs were studied using UV and CD spectroscopy. The results indicate that, similar to Dst, these analogs bind to DNA via the minor groove with a specificity towards AT-base pairs. It may be proposed that pyrrole chromophores in Dst probably do not play a role in the AT-base selectivity exhibited by Dst.

Item Type:	Journal Article
Publication:	FEBS Letters
Publisher:	Elsevier
Additional Information:	The Copyright belongs to Elsevier.
Keywords:	Drug-DNA interaction;Distamycin analog;AT-base specificity;Minor groove binding
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	03 Jun 2006
Last Modified:	19 Sep 2010 04:29
URI:	http://eprints.iisc.ac.in/id/eprint/7515

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