Superparamagnetic Nickel Nanocluster-Embedded MoS2Nanosheets for Gram-Selective Bacterial Adhesion and Antibacterial Activity

Ali, SR and De, M (2022) Superparamagnetic Nickel Nanocluster-Embedded MoS2Nanosheets for Gram-Selective Bacterial Adhesion and Antibacterial Activity. In: ACS Biomaterials Science and Engineering, 8 (7). pp. 2932-2942.

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Abstract

Ever increasing infectious diseases caused by pathogenic bacteria are creating one of the greatest health problems. The extensive use of numerous antibiotics and antimicrobial agents has prompted the growth of multidrug-resistant bacterial strains. The ancient biomedical application of metals and the recent advancement in the field of nanotechnology have encouraged us to explore the antimicrobial activity of nanomaterials. Herein, we have synthesized a magnetically separable superparamagnetic nickel nanocluster-loaded two-dimensional molybdenum disulfide nanocomposite (Ni@2D-MoS2). It can selectively bind with Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis over Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa. After the functionalization of Ni@2D-MoS2 with a positively charged ligand, it showed an excellent Gram-selective antibacterial activity toward MRSA and E. faecalis. Furthermore, the superparamagnetic property of the synthesized material can be used for the simultaneous removal and killing of the microbes and recycled for further use. This study demonstrates strategies to develop hybrid antimicrobial nanomaterial systems for selective antibacterial activity with recyclability.

Item Type:	Journal Article
Publication:	ACS Biomaterials Science and Engineering
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to the American Chemical Society.
Keywords:	Antimicrobial agents; Escherichia coli; Medical applications; Molybdenum disulfide; Nanoclusters; Nanocomposites; Nickel; Superparamagnetism, 2d molybdenum disulphide (2d-MoS2); Anti-bacterial activity; Bacterial adhesion; Gram selectivity; Infectious disease; Magnetic nanocomposites; Methicillin-resistant staphylococcus aureus; Nickel-nanoclusters; Pathogenic bacterium; Superparamagnetics, Layered semiconductors
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	21 Jul 2022 05:20
Last Modified:	21 Jul 2022 05:20
URI:	https://eprints.iisc.ac.in/id/eprint/74962

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