Kori, RS and Aladkatti, RH and Desai, SD and Das, KK (2017) Effect of anti-stress activity of Fluoxetine on restrained stress induced male albino rats in hematological parameters and whole brain histopathology. In: Journal of Young Pharmacists, 9 (2). pp. 246-250.
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Abstract
Objective: In this study we investigated the effect of Fluoxetine, a selective serotonin reuptake inhibitor, on the gravimetry, hematology and whole brain histopathology in the restrained stressed male albino rats. Methodology: Adult male Wistar albino rats weighing about 175-225 g were taken for the study and were divided into four groups of six animals each. Group I (control), Group II (stress induced), Group III (stress + withdrawal) and Group IV (stress + Fluoxetine, 20 mg/kg body weight, i.p.). The gravimetrical parameters, hematological parameters and whole brain histopathology of all the experimental rats were evaluated. Results: After 42 days of restraint stress, there was a significant (P.0.05) decrease final body weight, whole brain weight, Hb, RBC, MCV, MCH, total WBC and Platelets, whereas increase in Neutrophils, lymphocytes, eosinophils and monocytes in Group II of restraint stress rats when compared with their control group I. The stress withdrawal group (Group III) and drug Fluoxetine treatment (Group IV) shown significantly (P.0.05) improvement in gravimetry, hematological parameters and whole brain histopathology in restraint stress compared to only stress induced group II. Conclusion: The drug Fluoxetine treatment could exert a protective effect on restrained stress induced alterations in gravimetrical parameters, hematological parameters and whole brain histopathology of male albino rats.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Young Pharmacists |
| Publisher: | EManuscript Services |
| Additional Information: | The copyright for this article belongs to Journal of Young Pharmacists. |
| Keywords: | fluoxetine; hemoglobin, adult; albino rat; animal experiment; animal tissue; Article; body weight; brain tissue; brain weight; chronic stress; controlled study; eosinophil count; erythrocyte count; gravimetry; hemoglobin blood level; histopathology; immobilization stress; leukocyte count; lymphocyte count; male; mean corpuscular hemoglobin; mean corpuscular volume; monocyte; neutrophil count; nonhuman; rat; thrombocyte count; tranquilizing activity |
| Department/Centre: | Division of Biological Sciences > Central Animal Facility (Formerly Primate Research Laboratory) |
| Date Deposited: | 20 Jul 2022 10:56 |
| Last Modified: | 20 Jul 2022 10:56 |
| URI: | https://eprints.iisc.ac.in/id/eprint/74923 |
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