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Reversible assessment of restrained stress after withdrawal in male albino rats

Desai, SD and Kori, RS and Aladakatti, RH (2017) Reversible assessment of restrained stress after withdrawal in male albino rats. In: Journal of Pharmaceutical Sciences and Research, 9 (10). pp. 1738-1742.

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This study was carried out to determine the influence of restrained stress and its withdrawal possible alteration on gravimetry, organ weight, hematological parameters and level of serum cortisol in male Wistar albino rats. Adult male rats weighing about 175 to 225g were taken for the study and were divided at random into three groups of six animals each. Group I (control), kept undisturbed in the metabolic cage throughout the 42 days experimental period. Group II (stress) rats were kept in a wire mesh restrainer for 6 hr/day for 42 days. Group III (stress+ withdrawal) rats were stressed for 21 days and withdrawal of stress premeditated for remaining 21 days (total 42 days). At the end of the study period, all the experimental rats were sacrificed and gravimetrical, organ weight, hematological parameters and serum cortisol level were evaluated. Results revealed that restrained stress being a psychological stress significant (P ≤0.05) change in the gravimetry, organ weight, hematological parameters and serum cortisol level. On the other hand, Group III of withdrawal of stress exhibits subsequent improvement in these alterations may probably neutralize restrained stress induced damage that lead to oxidant antioxidant balance and alter hypothalamic-pituitary- adrenal (HPA) axis.

Item Type: Journal Article
Publication: Journal of Pharmaceutical Sciences and Research
Publisher: Pharmainfo Publications
Additional Information: The copyright for this article belongs to the Pharmainfo Publications.
Keywords: corticotropin; hydrocortisone; neurohormone, adrenal gland; adrenal hyperplasia; anemia; antioxidant activity; Article; blood pressure; body weight; brain weight; controlled study; decapitation; enzyme linked immunosorbent assay; eosinophil count; erythrocyte count; glucose metabolism; gravimetry; heart output; heart rate; hematological parameters; hemoglobin blood level; hydrocortisone blood level; hypertrophy; immunostimulation; kidney mass; liver weight; lymphocyte count; male; mean corpuscular hemoglobin; mean corpuscular volume; mental stress; monocyte; neutrophil count; nonhuman; organ weight; protein metabolism; rat; restrained stress; stress; sweating; testis weight; thrombocyte count
Department/Centre: Division of Biological Sciences > Central Animal Facility (Formerly Primate Research Laboratory)
Date Deposited: 17 Jul 2022 05:36
Last Modified: 17 Jul 2022 05:36
URI: https://eprints.iisc.ac.in/id/eprint/74474

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