Sahoo, D and Behera, SP and Shakya, J and Kaviraj, B (2022) Cost-effective synthesis of 2D molybdenum disulfide (MoS2) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging. In: PLoS ONE, 17 (1).
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Abstract
Ultrasmall MoS2 nanocrystals have unique optoelectronic and catalytic properties that have acquired significant attraction in many areas. We propose here a simple and economical method for synthesizing the luminescent nanocrystals MoS2 using the hydrothermal technique. In addition, the synthesized MoS2 nanocrystals display photoluminescence that is tunable according to size. MoS2 nanocrystals have many advantages, such as stable dispersion, low toxicity and luminescent characteristics, offering their encouraging applicability in biomedical disciplines. In this study, human lung cancer epithelial cells (A549) are used to assess fluorescence imaging of MoS2 nanocrystals. MTT assay, trypan blue assay, flow cytometry and fluorescence imaging results have shown that MoS2 nanocrystals can selectively target and destroy lung cancer cells, especially drug-resistant cells (A549). © 2022 Sahoo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
| Item Type: | Journal Article |
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| Publication: | PLoS ONE |
| Publisher: | Public Library of Science |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | molybdenum disulfide nanocrystal; nanocrystal; reactive oxygen metabolite; unclassified drug; disulfide; molybdenum; molybdenum disulfide, A-549 cell line; Article; cell metabolism; cell viability assay; concentration (parameter); controlled study; cost effectiveness analysis; cytotoxicity; flow cytometry; fluorescence imaging; human; human cell; molecular imaging; MTT assay; particle size; Raman spectrometry; transmission electron microscopy; two-dimensional imaging; X ray diffraction, Disulfides; Molybdenum |
| Department/Centre: | Division of Physical & Mathematical Sciences > Physics |
| Date Deposited: | 14 Jul 2022 04:46 |
| Last Modified: | 14 Jul 2022 04:46 |
| URI: | https://eprints.iisc.ac.in/id/eprint/74342 |
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