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Fast-Dip Layer-by-Layer Self-Assembly of Polyelectrolytes as a Low-Cost Biosensing Platform

Boranna, R and Vishwaraj, NP and Pahal, S and Nataraj, CT and Jagannath, RK and Nanjunda, SB and Prashanth, GR (2022) Fast-Dip Layer-by-Layer Self-Assembly of Polyelectrolytes as a Low-Cost Biosensing Platform. In: Macromolecular Chemistry and Physics .

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Official URL: https://doi.org/10.1002/macp.202200054


Polyelectrolyte multilayer (PEM) films fabricated using Layer-by-Layer (LbL) self-assembly are most versatile for numerous surface tailoring applications. Physicochemical customization of PEM at a nanometer scale is possible by choice of incorporated materials, assembly parameters, and assembly techniques. Conventional dip (CDip) (10–15 min dip time) coating dominates the PEM fabrication due to its simple, geometry-independent, and economical coating capabilities. Deposition of the PEM in CDip-LbL happens in two phases, that is, the initial adsorption phase followed by rearrangement of the complementary polyelectrolyte chains. By shortening the prolonged rearrangement phase, thicker stratified PEM films can form with a reduced dipping time (1 min), called Fast Dip (FDip). This reduction in the dipping time is studied in situ using Etched Fiber Bragg Grating-based sensors. To define the practical utility of the FDip deposited PEM, bio-molecular loading studies are performed using biotin and Bovine Serum Albumin (BSA). FDip-LbL is as effective as CDip-LbL self-assembly and also better than spin-LbL. Thus, the FDip deposition prompts a scalable LbL self-assembly process for quick fabrication of the biosensing platforms.

Item Type: Journal Article
Publication: Macromolecular Chemistry and Physics
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to the John Wiley and Sons Inc.
Keywords: Costs; Deposition; Fiber Bragg gratings; Mammals; Multilayer films; Multilayers; Polyelectrolytes; Self assembly; Spinning (fibers), Biosensing; Biosensing platforms; Dipping time; Etched fiber bragg grating; Fast-dip; Layer by layer; Layer by layer self assembly; Layer-by-layer self-assembly; Polyelectrolyte multilayer; Polyelectrolyte multilayer film, Coatings
Department/Centre: Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited: 28 Jun 2022 09:43
Last Modified: 28 Jun 2022 09:43
URI: https://eprints.iisc.ac.in/id/eprint/73983

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