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Tumor Hybrid Cells: Nature and Biological Significance

Tretyakova, MS and Subbalakshmi, AR and Menyailo, ME and Jolly, MK and Denisov, EV (2022) Tumor Hybrid Cells: Nature and Biological Significance. In: Frontiers in Cell and Developmental Biology, 10 .

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Official URL: https://doi.org/10.3389/fcell.2022.814714


Metastasis is the leading cause of cancer death and can be realized through the phenomenon of tumor cell fusion. The fusion of tumor cells with other tumor or normal cells leads to the appearance of tumor hybrid cells (THCs) exhibiting novel properties such as increased proliferation and migration, drug resistance, decreased apoptosis rate, and avoiding immune surveillance. Experimental studies showed the association of THCs with a high frequency of cancer metastasis; however, the underlying mechanisms remain unclear. Many other questions also remain to be answered: the role of genetic alterations in tumor cell fusion, the molecular landscape of cells after fusion, the lifetime and fate of different THCs, and the specific markers of THCs, and their correlation with various cancers and clinicopathological parameters. In this review, we discuss the factors and potential mechanisms involved in the occurrence of THCs, the types of THCs, and their role in cancer drug resistance and metastasis, as well as potential therapeutic approaches for the prevention, and targeting of tumor cell fusion. In conclusion, we emphasize the current knowledge gaps in the biology of THCs that should be addressed to develop highly effective therapeutics and strategies for metastasis suppression. Copyright © 2022 Tretyakova, Subbalakshmi, Menyailo, Jolly and Denisov.

Item Type: Journal Article
Publication: Frontiers in Cell and Developmental Biology
Publisher: Frontiers Media S.A.
Additional Information: The copyright for this article belongs to the Authors.
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 21 Jun 2022 08:46
Last Modified: 21 Jun 2022 08:46
URI: https://eprints.iisc.ac.in/id/eprint/73857

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