Divate, M and Tyagi, A and Richard, DJ and Prasad, PA and Gowda, H and Nagaraj, SH (2022) Deep Learning-Based Pan-Cancer Classification Model Reveals Tissue-of-Origin Specific Gene Expression Signatures. In: Cancers, 14 (5).
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Abstract
Cancer tissue-of-origin specific biomarkers are needed for effective diagnosis, monitoring, and treatment of cancers. In this study, we analyzed transcriptomics data from 37 cancer types provided by The Cancer Genome Atlas (TCGA) to identify cancer tissue-of-origin specific gene expression signatures. We developed a deep neural network model to classify cancers based on gene expression data. The model achieved a predictive accuracy of >97 across cancer types indicating the presence of distinct cancer tissue-of-origin specific gene expression signatures. We interpreted the model using Shapley additive explanations to identify specific gene signatures that significantly contributed to cancer-type classification. We evaluated the model and the validity of gene signatures using an independent test data set from the International Cancer Genome Consortium. In conclusion, we present a robust neural network model for accurate classification of cancers based on gene expression data and also provide a list of gene signatures that are valuable for developing biomarker panels for determining cancer tissue-of-origin. These gene signatures serve as valuable biomarkers for determining tissue-of-origin for cancers of unknown primary.
| Item Type: | Journal Article |
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| Publication: | Cancers |
| Publisher: | MDPI |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | Cancer type prediction; Deep learning; Gene expression signatures; Pan cancer |
| Department/Centre: | Division of Electrical Sciences > Electrical Communication Engineering |
| Date Deposited: | 30 Jun 2022 05:30 |
| Last Modified: | 30 Jun 2022 05:30 |
| URI: | https://eprints.iisc.ac.in/id/eprint/73788 |
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