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Roadmap on plasticity and epigenetics in cancer

Foo, J and Basanta, D and Rockne, RC and Strelez, C and Shah, C and Ghaffarian, K and Mumenthaler, SM and Mitchell, K and Lathia, JD and Frankhouser, D and Branciamore, S and Kuo, Y-H and Marcucci, G and Velde, RV and Marusyk, A and Huang, S and Hari, K and Jolly, MK and Hatzikirou, H and Poels, KE and Spilker, ME and Shtylla, B and Robertson-Tessi, M and Anderson, ARA (2022) Roadmap on plasticity and epigenetics in cancer. In: Physical Biology, 19 (3).

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Official URL: https://doi.org/10.1088/1478-3975/ac4ee2


The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions: is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts? © 2022 The Author(s). Published by IOP Publishing Ltd.

Item Type: Journal Article
Publication: Physical Biology
Publisher: Institute of Physics
Additional Information: The copyright for this article belongs to the Authors.
Keywords: epigenetics; genetic epigenesis; genetics; human; mutation; neoplasm; tumor microenvironment, Epigenesis, Genetic; Epigenomics; Humans; Mutation; Neoplasms; Tumor Microenvironment
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 21 Jun 2022 05:06
Last Modified: 21 Jun 2022 05:06
URI: https://eprints.iisc.ac.in/id/eprint/73652

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