The non-canonical nuclear functions of key players of the PI3K-AKT-MTOR pathway

Gupta, S and Kumar, M and Chaudhuri, S and Kumar, A (2022) The non-canonical nuclear functions of key players of the PI3K-AKT-MTOR pathway. In: Journal of Cellular Physiology .

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Abstract

The PI3K-AKT-MTOR signal transduction pathway is one of the essential signalling cascades within the cell due to its involvement in many vital functions. The pathway initiates with the recruitment of phosphatidylinositol-3 kinases (PI3Ks) onto the plasma membrane, generating phosphatidylinositol-3,4,5-triphosphate PtdIns(3,4,5)P3 and subsequently activating AKT. Being the central node of the PI3K network, AKT activates the mechanistic target of rapamycin kinase complex 1 (MTORC1) via Tuberous sclerosis complex 2 inhibition in the cytoplasm. Although the cytoplasmic role of the pathway has been widely explored for decades, we now know that most of the effector molecules of the PI3K axis diverge from the canonical route and translocate to other cell organelles including the nucleus. The presence of phosphoinositides (PtdIns) inside the nucleus itself indicates the existence of a nuclear PI3K signalling. The nuclear localization of these signaling components is evident in regulating many nuclear processes like DNA replication, transcription, DNA repair, maintenance of genomic integrity, chromatin architecture, and cell cycle control. Here, our review intends to present a comprehensive overview of the nuclear functions of the PI3K-AKT-MTOR signaling biomolecules. © 2022 Wiley Periodicals LLC.

Item Type:	Journal Article
Publication:	Journal of Cellular Physiology
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to the John Wiley and Sons Inc.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	06 Jun 2022 05:13
Last Modified:	06 Jun 2022 05:13
URI:	https://eprints.iisc.ac.in/id/eprint/73121

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