Muniraj, Nachimuthu and Prabhu, Kandikere Ramaiah (2017) Co(III)-Catalyzed C–H Activation: A Site-Selective Conjugate Addition of Maleimide to Indole at the C-2 Position. In: ACS Omega, 2 (8). pp. 4470-4479. ISSN 2470-1343
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Abstract
The cobalt(III)-catalyzed site-selective C-2 functionalization of indole has been developed using the pyrimidinyl group as a directing group. This reaction furnishes 3-arylated succinimide derivatives in excellent yields in a shorter duration using an inexpensive Co catalyst. Highly selective C-2 functionalization of indoles was achieved in the presence of the highly reactive C-3 position. This protocol is compatible with a variety of N-pyrimidinyl indole and maleimide derivatives, and it can be easily scaled-up. This method is also applicable for maleic ester and heteroarenes.
| Item Type: | Journal Article |
|---|---|
| Publication: | ACS Omega |
| Publisher: | American Chemical Society |
| Additional Information: | The Copyright of this article belongs to the American Chemical Society |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 07 Jun 2022 06:06 |
| Last Modified: | 07 Jun 2022 06:06 |
| URI: | https://eprints.iisc.ac.in/id/eprint/72944 |
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