Mishra, SK and Chaudhari, SR and Lakshmipriya, A and Pal, I and Lokesh, N and Suryaprakash, N (2017) Novel Synthetic As Well As Natural Auxiliaries With a Blend of NMR Methodological Developments for Chiral Analysis in Isotropic Media. [Book Chapter]
Full text not available from this repository.Abstract
Chiral auxiliaries are routinely employed in the NMR spectroscopic discrimination of enantiomers in isotropic solutions. Most of the times the presence of impurities, superposition of peaks, enormous line broadening, and complex multiplicity pattern limit the NMR spectroscopic discrimination of enantiomers and determination of their composition. There are a few approaches to unravel the overlap of peaks. A simple approach is to utilize appropriate chiral auxiliary, which induces a large chemical shift difference between the discriminated peaks (Δδ)R/S, and minimize or unravel the overlap of peaks. In this direction, several new chiral auxiliaries and new chiral differentiation protocols have been introduced, which are both synthetic and naturally occurring molecules. An alternate spectroscopic approach is to design NMR experiments to circumvent inherent problems, viz., enhancing the spectral resolution, separation of the superimposed spectra of enantiomers, and reduction of the spectral complexity. A large number of NMR experiments, such as two-dimensional selective F1 decoupling, RES-TOCSY, multiple quantum detection, frequency-selective homodecoupling, band-selective homodecoupling, and broadband homodecoupling called as pure shift NMR, to cite a few, are available for such a purpose. Many of these techniques have simplified the chiral analysis for molecules containing diverse functional groups in the presence of suitable chiral auxiliaries. The present chapter summarizes the work carried out in the authors’ laboratory on chiral analysis. This includes the recently introduced new chiral auxiliaries, which are either synthesizable or natural products. They could be either derivatizing agents or solvating agents or the developed three-component protocols, in addition to new NMR experimental methodologies.
| Item Type: | Book Chapter |
|---|---|
| Publisher: | Academic Press Inc. |
| Additional Information: | The copyright of this article belongs to the Academic Press Inc. |
| Keywords: | Chiral discrimination; Derivatizing agent; Solvating agent; Three-component protocols; Ion-pair complexation;RNA nucleosides;Epigallocatechin gallate; Helicin; Enantiomeric excess; Multiple quantum NMR; RES-TOCSY technique; J-Resolved technique |
| Department/Centre: | Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility) Division of Chemical Sciences > Solid State & Structural Chemistry Unit |
| Date Deposited: | 29 May 2022 08:46 |
| Last Modified: | 31 May 2022 00:46 |
| URI: | https://eprints.iisc.ac.in/id/eprint/72803 |
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