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Biodegradable Polymers for Protein and Peptide Therapeutics: Next Generation Delivery Systems

Dyawanapelly, Sathish and Jain, Nishant Kumar and KR, Sindhu and Prasanna, Maruthi and Singh, Akhilesh Vikram (2017) Biodegradable Polymers for Protein and Peptide Therapeutics: Next Generation Delivery Systems. [Book Chapter]

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Official URL: https://doi.org/10.1002/9781119441632.ch18


Over the past decades, therapeutic use of many protein and peptides are hampered by in vitro and in vivo stability, short-half life and immunogenicity. To address an unmet need of protein therapeutics, biologists and chemists together have invented polymerprotein conjugates. These polymer-protein therapeutics have successfully developed and investigated extensively with a variety of natural and synthetic biodegradable polymers such as poly (ethylene glycol), polysialic acid, polyglycerol, polyamidoamine, poly (methyl methacrylate), poly(hydroxyethyl methacrylate), poly(N-isopropylacrylamide), poly(ethylene glycol) methyl ether acrylate, poly(N-vinylpyrrolidone), dextran, dextrin, hyaluronic acid and hydroxylethyl starch. Polymer-protein therapeutics has attracted tremendous attention in the last few years. Such strategies have the potential to develop as next generation protein therapeutics. This chapter will highlight synthesis strategies, design concepts, recent progress, clinical studies and future prospects for protein-and peptide-polymer conjugates.

Item Type: Book Chapter
Publisher: wiley
Additional Information: The Copyright of this article belongs to the wiley
Keywords: Hyperglycosylation; Pegylation; Peptide; Polymer conjugation; Protein; Protein delivery; Acrylic monomers; Amides; Biodegradable polymers; Biosynthesis; Esters; Ethylene glycol; Hyaluronic acid; Peptides; Polyethylene glycols; Polyols; Proteins; Hyperglycosylation; Methyl ether acrylate; PEgylation; Poly (n isopropylacrylamide); Poly hydroxy ethyl methacrylates; Polymer-protein conjugates; Protein delivery; Synthetic biodegradable polymers; Functional polymers
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 25 May 2022 04:45
Last Modified: 25 May 2022 04:45
URI: https://eprints.iisc.ac.in/id/eprint/72547

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