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BRCA Role Changes with Association: Tissue-specific impact on the prognosis

Gupta, Bhavana and Somasundaram, Kumaravel (2021) BRCA Role Changes with Association: Tissue-specific impact on the prognosis. In: Oncotarget, 12 (26). pp. 2541-2542. ISSN 1949-2553

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Official URL: https://doi.org/10.18632/ONCOTARGET.28149


The tumor suppressor BRCA (BReast CAncer) genes are majorly involved in biological processes such as DNA damage response, gene transcription regulation, cell cycle, and apoptosis. It was identified in the early 90s that germ line mutations in BRCA1 increase the risk of breast and ovarian cancer [1]. Subsequently, several studies in breast cancer patients found an association of BRCA1 expression levels and mutation status with the patient survival. BRCA genes correlated with favorable overall survival (OS) in some cancers, while opposing effects have also been reported [2]. There are several speculations about this tissue-specificity of BRCA1 gene, but only a few attempts have been made to analyze these theories systematically or experimentally.

Item Type: Journal Article
Publication: Oncotarget
Additional Information: The copyright of this article belongs to the authors.
Keywords: BRCA1; prognosis; tissue-specificity
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 20 May 2022 11:21
Last Modified: 20 May 2022 11:21
URI: https://eprints.iisc.ac.in/id/eprint/72443

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